Virginia Dare, born in 1587, was the first person born in America to English parents.
Here are a few more Famous Firsts by U.S. women:
1650Ann Bradstreet 1st Published U.S. WriterAnne Bradstreet's book of poems, The Tenth Muse Lately Sprung Up in America, is published in England. 1707Henrietta Johnston 1st Professional U.S. FemaleMore >> 1767Anne Catherine Hoof Green 1st U.S. Woman to Run a Print ShopAnne Catherine Hoof Green takes over her late husband's printing and newspaper business, becoming the first American woman to run aMore >> 1872Victoria Claflin Woodhull 1st U.S. Female Presidential CandidateVictoria Claflin Woodhull becomes the first woman presidential candidate in the United States when she is nominated by the NationalMore >> 1926Gertrude EderleAmerican Gertrude Ederle becomes the first woman to swim across the English Channel. 1931Maxine DunlapMaxine Dunlap becomes first American woman to earn a glider pilot license. 1932AmeliaMore >>