Officials were called to scene of a motorcycle and car crash at the intersection of Bower and East Dwight Streets around 7 p.m. on Saturday.
Sgt. John Hart of the Holyoke Police Department told CBS 3 that the motorcyclist, who was male, died from the crash.
He was initially taken to Baystate Medical Center.
Hart said the motorcycle exploded into flames after colliding with the car.
The Holyoke accident reconstruction team was called to the scene.
The crash remains under investigation.
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