CLEMSON, S.C. (AP) - Shawnta Dyer had a season-high 20 points, Miraya Moore scored 15 and No. 9 Louisville cruised to an 81-49 win over Clemson on Thursday night.
Sara Hammond added 12 points and Myisha Hines-Allen 10 to help the Cardinals (21-3, 9-2 Atlantic Coast Conference) win for the fourth time in five games.
Louisville used a quick start and a 19-2 run that straddled both halves to go to 4-0 all-time against the Tigers.
Nikki Dixon and Shelbie Davenport scored 10 points apiece to lead Clemson (9-16, 1-11), which couldn't handle Louisville's ACC-leading defense and lost its 11th straight. The Tigers have lost 72 of their past 73 games against ranked opponents.
The Cardinals opened with a 21-5 burst and turned things up again with its big run after the Tigers cut the lead to 10 points late in the opening period.