The Giants threw a scare into the Panthers, but Carolina answered the challenge and remains unbeaten.
Cam Newton led the Panthers on a game-winning drive in the final minutes and Graham Gano booted a 43-yard field goal as time expired to give Carolina a 38-35 win over New York.
The Giants rallied from 28 points down to tie the game with 1:46 to go on and Eli Manning-to-Odell Beckham, Jr. fourth down pass.
But Newton marched the Panthers down field for Gano's game-winner to give Carolina a 14-0 record.
Newton threw five touchdown passes, while Manning tossed four.